|
T12746 |
ROCK inhibitor-2
|
|
ROCK
|
|
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively). |
|
T4095 |
ZINC00881524
|
ROCK inhibitor |
ROCK
|
|
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor. |
|
T6867 |
Belumosudil
|
KD025,Rezurock,ROCK inhibitor,SLx-2119 |
ROCK
|
|
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM). |
|
T12747 |
ROCK2-IN-2
|
|
ROCK
|
|
|
|
TQ0110 |
ROCK-IN-2
|
TC-S 7001,Azaindole 1 |
ROCK
|
|
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2. |
|
T2011 |
RKI1313
|
RKI 1313,RKI-1313 |
ROCK
|
|
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion. |
|
T2155 |
Thiazovivin
|
|
ROCK
|
|
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC. |
|
T1870 |
Y-27632
|
|
ROCK
,
Apoptosis
|
|
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. |
|
T24722 |
ROCK-IN-32
|
ROCK-inhibitor-32,ROCK inhibitor 32 |
|
|
ROCK-IN-32 is an effective Rho-kinase inhibitor. |
|
T24725 |
ROCK-IN-D3
|
ROCK inhibitor D3,ROCK-inhibitor-D3 |
|
|
ROCK-IN-D3 is an effective and selective inhibitor of ROCK. |
|
TQ0187 |
SR-3677
|
|
ROCK
,
Autophagy
|
|
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). |
|
T24723 |
ROCK-IN-D1
|
ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1 |
|
|
ROCK-IN-D1 is an effective and selective inhibitor of ROCK. |
|
T24724 |
ROCK-IN-D2
|
ROCK inhibitor D2,ROCK IN D2,ROCK-inhibitor-D2 |
|
|
ROCK-IN-D2 is an effective and selective inhibitor of ROCK. |
|
T7391 |
SAR407899
|
|
ROCK
,
Rho
|
|
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. |
|
T15798 |
LX7101
|
|
ROCK
,
LIM Kinase
,
PKA
|
|
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM). |
|
T7301 |
BDP5290
|
|
ROCK
|
|
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.) |
|
T1898 |
RKI-1447
|
RKI1447 |
ROCK
|
|
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. |
|
T3513 |
GSK180736A
|
GSK180736 |
ROCK
,
GRK
,
PKA
|
|
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM). |
|
T14960 |
Chroman 1
|
|
ROCK
|
|
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM). |
|
T2633 |
GSK429286A
|
RHO-15 |
ROCK
|
|
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM). |
|
T14989 |
CMPD101
|
|
ROCK
,
GRK
,
PKC
|
|
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I... |
|
T7885 |
Afuresertib hydrochloride
|
|
ROCK
,
Akt
,
PKC
|
|
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively) |
|
T4488 |
GSK-25
|
GSK25 |
ROCK
,
S6 Kinase
,
mTOR
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
|
T13384L |
Y-33075 dihydrochloride
|
|
CaMK
,
ROCK
,
PKC
|
|
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM). |
|
T7648 |
HA-100
|
|
Myosin
,
PKA
,
PKC
|
|
HA-100 is an inhibitor of protein kinase |
|
T2482 |
AT13148
|
|
ROCK
,
SGK
,
Akt
,
PKA
,
S6 Kinase
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. |
|
T4276L |
Hydroxyfasudil
|
Hydroxy-Fasudil,HA-1100 |
ROCK
,
PKA
|
|
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively). |
|
T1911 |
Afuresertib
|
GSK2110183C,GSK2110183 |
ROCK
,
Akt
,
PKC
|
|
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. |
|
T7764 |
CCG-222740
|
|
ROCK
,
Rho
,
Ras
|
|
CCG-222740 is an inhibitor of Rho/MRTF pathway |
|
TQ0319 |
Ripasudil
|
K-115,Ripasudil hydrochloride dihydrate |
ROCK
|
|
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2). |
|
T3518 |
GSK269962A
|
GSK269962B,GSK 269962,GSK269962A HCl |
ROCK
,
S6 Kinase
|
|
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
|
T23308 |
SAR407899 hydrochloride
|
|
ROCK
|
|
ATP-competitive ROCK inhibitor |
|
T4276 |
Hydroxyfasudil Hydrochloride
|
Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride |
ROCK
|
|
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM). |
|
T7552 |
H-1152
|
|
ROCK
|
|
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM). |
|
T1725 |
Y-27632 dihydrochloride
|
Y-27632 2HCl |
ROCK
,
Apoptosis
|
|
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells. |
|
T1606 |
Fasudil
|
HA-1077,AT877 |
ROCK
,
Serine/threonin kinase
,
Calcium Channel
,
PKA
,
PKC
,
Autophagy
|
|
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK. |
|
T7492 |
Ripasudil free base
|
K-115 (free base) |
ROCK
,
Antibacterial
|
|
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent. |
|
T3060 |
Fasudil hydrochloride
|
Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 |
ROCK
,
Serine/threonin kinase
,
Calcium Channel
,
HIV Protease
,
PKA
,
PKC
,
Autophagy
|
|
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively. |
|
T36196 |
CAY10746
|
|
ROCK
|
|
CAY10746 is a selective Rho kinase (ROCK) inhibitor that inhibits ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.CAY10746 can be used to study diabetic retinopathy. |
|
T13419 |
ROCK-IN-1
|
|
ROCK
|
|
ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological disorders and inflammation-related diseases. |
|
T67748 |
ROCK-IN-5
|
|
ROCK
,
ERK
|
|
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferative and neurodegenerative diseases research. |
|
T69665 |
Zelasudil
|
|
|
|
Zelasudil, a Rho-associated (ROCK) kinase inhibitor, demonstrates a binding affinity for ROCK2. |
|
T26078 |
Rhodblock 6
|
Rhodblock6,Rhodblock-6 |
ROCK
|
|
Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits the localization of phosphorylated MRLC (Myosin Regulatory Light Chain) and acts by specifically inhibiting Rho kinase activity. |
|
T10358 |
Netarsudil Dihydrochloride
|
AR-13324 Dihydrochloride |
ROCK
|
|
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction. |
|
T10888 |
CRT0066854 hydrochloride
|
|
ROCK
,
PKC
|
|
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively. |
|
T38654 |
Cotosudil
|
|
ROCK
|
|
Cotosudil is a ROCK kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or neurodegenerative diseases or nerve damage. |
|
T12721 |
Rho-Kinase-IN-1
|
|
ROCK
|
|
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise... |
|
T35328 |
H-1152 dihydrochloride
|
H-1152 2HCl,H-1152 dihydrochloride |
ROCK
|
|
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 ... |
|
T60924 |
Verosudil
|
AR-12286 |
ROCK
|
|
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-induced intraocular pressure in mice by decreasing intraocular ... |
|
T22037 |
AS 1892802
|
|
ROCK
|
|
AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respectively. The onset of antinociceptive effect of AS 1892802 ... |
